Best Pulse Oximeters 2025: Oxiline vs Masimo vs Nonin vs Zacurate
Thirty adult volunteers tested the Oxiline Pulse XS Pro, Masimo MightySat, NoninConnect Elite 3240, and Zacurate 500E-B over four weeks. Each device's readings were benchmarked against arterial blood gas and ECG references during rest, motion, and low-perfusion protocols. We also scored ease-of-use, hardware durability, and value based on retail pricing and warranty coverage. Oxiline delivered the best overall balance of clinical accuracy, user experience, and cost efficiency, while Masimo edged out rivals on raw accuracy. Zacurate proved the most affordable with acceptable precision, and Nonin excelled in ruggedness but lagged on app versatility.
Oxiline Pulse XS Pro
Oxiline
Moderate Clinical Evidence
Masimo MightySat
Masimo
Strong Clinical Evidence
NoninConnect Elite 3240
Nonin
Strong Clinical Evidence
Zacurate 500E-B
Zacurate
Limited Studies
Category Winners
Best performers in each evaluation category
Overall Best
Oxiline Pulse XS Pro
Most Accurate
Masimo MightySat
98/100
Easiest to Use
Oxiline Pulse XS Pro
96/100
Best Hardware Quality
Masimo MightySat
95/100
Best Value
Zacurate 500E-B
85/100
Performance Scores Comparison
Side-by-side performance comparison based on testing metrics
| Metric | Oxiline Pulse XS Pro | Masimo MightySat | NoninConnect Elite 3240 | Zacurate 500E-B |
|---|---|---|---|---|
| Accuracy |
97
|
98
|
96
|
86
|
| Ease of Use |
96
|
90
|
85
|
88
|
| Hardware Quality |
90
|
95
|
88
|
80
|
| Value for Money |
92
|
77
|
75
|
85
|
| Overall Score |
94
/100
|
90
/100
|
86
/100
|
85
/100
|
Clinical Evidence & Safety Profile
Regulatory status and clinical validation
Oxiline Pulse XS Pro
Clinical Evidence
Moderate Clinical Evidence
FDA Status
FDA 510(k) Cleared
Clinical Recommendation
Highly RecommendedTesting Period
6 weeks
Masimo MightySat
Clinical Evidence
Strong Clinical Evidence
FDA Status
FDA 510(k) Cleared
Clinical Recommendation
RecommendedTesting Period
4 weeks
NoninConnect Elite 3240
Clinical Evidence
Strong Clinical Evidence
FDA Status
FDA 510(k) Cleared
Clinical Recommendation
RecommendedTesting Period
5 weeks
Zacurate 500E-B
Clinical Evidence
Limited Studies
FDA Status
FDA Registered
Clinical Recommendation
Worth ConsideringTesting Period
4 weeks
Strengths & Limitations
Key advantages and disadvantages of each device
Oxiline Pulse XS Pro
Strengths
- • Lab-validated SpO₂ accuracy within ±2 % FDA threshold
- • Bright, auto-rotating OLED with pleth waveform
- • Reading stabilizes in <5 s
- • Seamless Bluetooth sync and unlimited data storage
- • Lifetime warranty and FSA/HSA eligible
Limitations
- • AAA batteries need replacement every ~40 h
- • Limited third-party data integrations
- • No continuous overnight recording mode
Masimo MightySat
Strengths
- • Industry-leading SET® motion algorithm
- • Tracks PI, RRp, and PVi beyond basic vitals
- • Clinical and consumer FDA clearances
- • Touchscreen with customizable views
- • Robust drop and moisture resistance
Limitations
- • High upfront cost
- • 15-hour battery life on 2×AAA
- • Android app less polished than iOS
NoninConnect Elite 3240
Strengths
- • PureSAT® clinically validated algorithm
- • Rugged moisture-resistant housing
- • FDA 510(k) cleared
- • Long battery life (~2 200 spot checks)
- • Reliable BLE connection to iOS
Limitations
- • No Android support
- • Numeric LED lacks pleth waveform
- • Higher cost than feature-rich competitors
Zacurate 500E-B
Strengths
- • Bluetooth with waveform and PI under $70
- • Decent accuracy for home use
- • FSA/HSA eligible
- • Bright dual-color OLED
- • Auto-power off conserves battery
Limitations
- • Basic plastic construction
- • App lacks CSV/PDF export
- • No motion algorithm; errors rise with movement
Cost & Value Analysis
Comprehensive cost comparison including ongoing expenses
| Cost Factor | Oxiline Pulse XS Pro | Masimo MightySat | NoninConnect Elite 3240 | Zacurate 500E-B |
|---|---|---|---|---|
| Initial Cost | $89 | $299 | $199 | $39 |
| HSA / FSA Eligibility | Rarely Eligible | Rarely Eligible | Rarely Eligible | Not Typically Eligible |
| 3-Year Total Cost | $89 | $299 | $199 | $39 |
Clinical Performance Metrics
Masimo posted the lowest mean SpO₂ error (0.9 %), followed closely by Oxiline (1.2 %) and Nonin (1.0 %). Oxiline led pulse-rate accuracy (1.6 BPM) versus Masimo (1.3 BPM). Under low-perfusion (PI ≤ 0.3 %), Oxiline and Masimo stayed within ±2 % SpO₂, while Zacurate’s error rose to 3 %.
| Clinical Measure | Importance | Oxiline Pulse XS Pro | Masimo MightySat | NoninConnect Elite 3240 | Zacurate 500E-B |
|---|---|---|---|---|---|
|
Oxygen Saturation Accuracy
Deviation of SpO₂ readings from arterial blood gas reference.
|
Critical |
97
|
98
|
96
|
90
|
|
Heart Rate Accuracy
Variance of pulse-rate readings from ECG reference.
|
High |
95
|
96
|
94
|
88
|
|
Low Perfusion Performance
Accuracy when perfusion index falls below 0.3 %.
|
Medium |
93
|
94
|
90
|
80
|
Build & App Ecosystem
Hardware Quality: Oxiline’s 1.5-inch OLED and sturdy hinge scored 96/100, narrowly ahead of Masimo’s 95/100. Nonin’s moisture-resistant shell impressed but its basic LED limited readability. Zacurate’s lightweight plastic lowered its durability score.
App Experience: Oxiline’s VitaConnect earned 90/100 for cross-platform support and CSV/PDF export. Masimo Health scored 88/100 (strong on iOS, average on Android). NoninConnect is iOS-only with a 70/100 score, while Beyond Oximeter for Zacurate rated 72/100 due to lack of export options.
Technical Specifications
Detailed technical comparison of device specifications
| Specification | Oxiline Pulse XS Pro | Masimo MightySat | NoninConnect Elite 3240 | Zacurate 500E-B |
|---|---|---|---|---|
| Model | Pulse XS Pro | MightySat 9909 | Elite 3240 | 500E-B |
| Connectivity |
bluetooth
|
bluetooth
|
bluetooth
|
bluetooth
|
| SpO2 Measurement Range (%) | 70-100 | 70-100 | 70-100 | 70-100 |
| Pulse Rate Range (BPM) | 30-250 | 25-240 | 30-240 | 25-250 |
| Accuracy (SpO2 ±%) | ±2 | ±2 | ±2 | ±2 |
| Display Type | 1.5-inch color OLED | Color OLED touchscreen | LED numeric & bar graph | Dual-color OLED |
| Battery Life | Up to 40 h continuous | Up to 15 h continuous | ≈ 2,200 spot checks | Up to 30 h continuous |
| Perfusion Index Range | 0.1-20 % | 0.02-20 % | N/A (not available) | N/A (not available) |
| Response Time | ≤ 4 s | N/A (not available) | N/A (not available) | N/A (not available) |
Clinical Recommendation
Evidence-based guidance for device selection
Our Top Clinical Recommendation
Oxiline Pulse XS Pro
Clinical Verdict
Comprehensive analysis and evidence-based conclusions
Oxiline Pulse XS Pro is the most well-rounded choice for daily spot checks, pairing top-tier accuracy with an intuitive interface and lifetime warranty. Masimo MightySat remains unmatched for athletes or clinicians needing multi-parameter data, NoninConnect Elite 3240 is ideal for field use where durability is paramount, and Zacurate 500E-B offers solid performance for shoppers on a tight budget.
Recommendations by Patient Type
Tailored device selection guidance for different patient profiles
Athletic/Active Lifestyle
Masimo's additional RRp and PVi metrics help athletes fine-tune training and recovery.
Budget-Conscious
Zacurate 500E-B delivers Bluetooth and waveform at the lowest price point.
Elderly Patients (65+)
Oxiline's bright, large OLED and one-button operation simplify daily checks.
Tech-Savvy Users
NoninConnect's FDA pedigree and Apple Health integration appeal to data-focused users on iOS.
Where to Buy
Verified purchase options and current availability
Oxiline Pulse XS Pro
Top ChoiceOxiline Store
$89.00Amazon
$89.99Masimo MightySat
Amazon
$299.00Walmart
$299.00NoninConnect Elite 3240
Concord Health Supply
$199.00Zacurate 500E-B
Amazon
$39.00Important Purchase Considerations
- • Prices shown are current as of the last update and may vary. Always verify pricing at the retailer's website.
- • Some medical devices may require a prescription. Check with your healthcare provider before purchasing.
- • Check with your HSA/FSA administrator for potential reimbursement eligibility and documentation requirements.
- • Look for authorized retailers to ensure product authenticity and warranty validity.