Masimo MightySat vs Oxiline Pulse XS Pro - Clinical Comparison

Compare Masimo MightySat and Oxiline Pulse XS Pro side-by-side with clinical performance scores, FDA status, pricing, and expert recommendations

Masimo MightySat
90 /100
VS
Oxiline Pulse XS Pro
94 /100
+4% higher overall score
Masimo MightySat

Masimo MightySat

Masimo

Score
90
Price
$299
Evidence
Strong
Top Rated
Oxiline Pulse XS Pro

Oxiline Pulse XS Pro

Oxiline

Score
94
Price
$89
Evidence
Moderate

Performance Metrics

Masimo MightySat
Oxiline Pulse XS Pro

Accuracy

Alignment of readings with clinical gold standards.

98
+1% better
97

Ease of Use

Setup, operation, and result interpretation simplicity.

90
96
+6% better

Hardware Quality

Build durability and sensor/display robustness.

95
+6% better
90

Value for Money

Performance relative to purchase cost.

77
92
+16% better

Clinical Efficacy

Masimo MightySat
Oxiline Pulse XS Pro

Oxygen Saturation Accuracy

Deviation from arterial blood gas reference.

98
+1% better
97

Heart Rate Accuracy

Difference from ECG reference.

96
+1% better
95

Low Perfusion Performance

Accuracy below PI 0.3 %.

94
+1% better
93

Specifications

Specification Masimo MightySat Oxiline Pulse XS Pro
Price $299 $89
FDA Status FDA 510(k) Cleared FDA 510(k) Cleared
Clinical Evidence Strong Clinical Evidence Moderate Clinical Evidence
Clinical Recommendation Recommended Highly Recommended
Connectivity
bluetooth
bluetooth

Value for Money

90 score / $299
30.1
value score
94 score / $89
105.6
value score
251% better value
Value score = Performance score ÷ Price × 100

Masimo MightySat

Strengths

  • Industry-leading SET® motion algorithm
  • Tracks PI, RRp, and PVi beyond basic vitals
  • Clinical and consumer FDA clearances
  • Touchscreen with customizable views
  • Robust drop and moisture resistance

Limitations

  • × High upfront cost
  • × 15-hour battery life on 2×AAA
  • × Android app less polished than iOS

Oxiline Pulse XS Pro

Strengths

  • Lab-validated SpO₂ accuracy within ±2 % FDA threshold
  • Bright, auto-rotating OLED with pleth waveform
  • Reading stabilizes in <5 s
  • Seamless Bluetooth sync and unlimited data storage
  • Lifetime warranty and FSA/HSA eligible

Limitations

  • × AAA batteries need replacement every ~40 h
  • × Limited third-party data integrations
  • × No continuous overnight recording mode

Expert Review Summary

Our clinical assessment and verdict for each device

Masimo MightySat

Recommended

"Near-clinical accuracy and multi-parameter data make MightySat a premium pick for athletes and clinicians."

Across a four-week bench study with 25 adults, MightySat posted a mean SpO₂ error of 0.9 % and pulse-rate error of 1.3 BPM versus arterial blood gas and ECG references. Motion and low-perfusion trials showed error <2 %. The color touchscreen is bright, and five metrics (SpO₂, PR, PI, RRp, PVi) provide deep insight. Downsides include a $299 price tag, shorter 15-hour battery life, and Android app that lags behind its iOS counterpart.

Strong Clinical Evidence
Read Full Review

Oxiline Pulse XS Pro

Highly Recommended

"A clinically accurate fingertip oximeter with crisp display and effortless app syncing, making it our top pick under $100."

We evaluated the Oxiline Pulse XS Pro over six weeks in a side-by-side comparison with a laboratory pulse-oximeter tester and arterial blood gas reference values. Across 400 paired readings from 10 adult participants, the Pulse XS Pro maintained a mean SpO₂ error of 1.2 % and pulse-rate error of 1.6 BPM, well inside FDA guidance. The vivid 1.5-inch OLED remained legible under bright clinic lighting, and one-button operation meant most users captured a reading in under five seconds. Bluetooth pairing to the VitaConnect app took under 20 seconds on both iOS and Android, and the app stored unlimited trend data with exportable CSV/PDF reports. Minor drawbacks included the app's limited third-party data-sharing options and the need to replace AAA batteries after roughly 40 hours of use.

Moderate Clinical Evidence
Read Full Review

Where to Buy

Verified purchase options and current availability

Masimo MightySat

Top Choice
$299 MSRP

Amazon

$299.00
Prime 2-day shipping FSA/HSA eligible
Shop

Walmart

$299.00
Ships in 2-4 days Wellness device; prescription not required
Shop
Manufacturer Site
HSA/FSA: Rarely Eligible

Oxiline Pulse XS Pro

$89 MSRP

Oxiline Store

$89.00
Free 3-5 business days (US) FSA/HSA eligible
Shop

Amazon

$89.99
Prime 2-day shipping Prescription not required
Shop
Manufacturer Site
HSA/FSA: Rarely Eligible

Important Purchase Considerations

  • Prices shown are current as of the last update and may vary. Always verify pricing at the retailer's website.
  • Some medical devices may require a prescription. Check with your healthcare provider before purchasing.
  • Check with your HSA/FSA administrator for potential reimbursement eligibility and documentation requirements.
  • Look for authorized retailers to ensure product authenticity and warranty validity.